Cost-effectiveness analysis for HbA1c test intervals to screen patients with type 2 diabetes based on risk stratification

نویسندگان

چکیده

Abstract Background The best HbA1c test interval strategy for detecting new type 2 diabetes mellitus (T2DM) cases in healthy individuals should be determined with consideration of characteristics, risk stratification towards T2DM and cost effectiveness. Methods State transition models were constructed to investigate the optimal screening among each age- BMI-stratified health individuals. Age was stratified into 30–44-, 45–59-, 60–74-year-old age groups, BMI also underweight, normal, overweight obesity. In model, different intervals evaluated respect incremental cost-effectiveness ratio (ICER) costs per quality-adjusted life year (QALY). Annual (Japanese current strategy), every 3 years (recommendations US UK) which are tailored group compared. All model parameters, including treatment, rates complications mortality utilities, taken from published studies. willingness-to-pay threshold analysis set $50,000/QALY. Results varies by BMI. Three-year most effective obesity at all ages—30-44: $15,034/QALY, 45–59: $11,849/QALY, 60–74: $8685/QALY—compared other two strategies. three-year groups—underweight: $11,377/QALY, normal: $18,123/QALY, overweight: $12,537/QALY—and 45–59-year-old group; $18,918/QALY. found longer than years, as previously reported. screenings dominated many groups low younger groups. Based on probability distribution ICER, results consistent any Conclusions elderly ages, ages group. For those sin low-BMI could years. detect not applied population.

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ژورنال

عنوان ژورنال: BMC Endocrine Disorders

سال: 2021

ISSN: ['1472-6823']

DOI: https://doi.org/10.1186/s12902-021-00771-0